Lionel Essrog, en ensom privatdetektiv, der lider af Tourettes syndrom, er opsat på at løse mysteriet om mordet på hans mentor, og eneste ven, Frank Minna. Bevæbnet med kun få spor, og sit neurotiske sind, afslører Lionel en række tæt bevarede hemmeligheder, der er afgørende for New Yorks skæbne. Hans søgen efter sandheden tager ham fra stemningsfyldte jazzklubber i Harlem til de hårde slumkvarterer i Brooklyn og sidst, men ikke mindst, til de forgyldte rum, som New Yorks magtfulde kerne begår sig i, og undervejs må Lionel kæmpe mod banditter, korruption og den farligste mand i byen samt redde kvinden, der måske kan blive hans egen redning.
" Edward Norton gør det ikke kun godt foran kameraet i film som ’Primal Fear’, ’Fight Club’ og ’Moonrise Kingdom’ for bare at nævne et par stykker. Norton er nemlig også instruktør og er lige nu aktuel med sin anden film ’Mortherless Brooklyn’. Filmen bygger på Jonathan Lethems roman af samme navn fra 1999 og handler om privatdetektiven Lionel Essrog, der har Tourettes syndrom. Nortons visuelle sprog er en kærlighedserklæring til 1950’ernes New York mens instruktøren selv er at finde i hovedrollen som den ihærdige detektiv. "
Lionel Essrog (Edward Norton) is not an ordinary private investigator. He is struggling with Tourette Syndrome, which means that the poor guy has a neurological disease hat makes him look so weird by involuntary eye blinking, coughing, throat clearing, sniffing, and making sudden facial movements. His mentor and only friend Frank Minna (Bruce Willis) helps Lionel turn his weakness into a strength and use it for good. Unfortunately, our man’s condition causes Frank’s death. Eager to solve the mystery of that murder, Lionel is left to rely on very few clues, small pieces of a puzzle that doesn’t look connected. It is the 1950s and from Harlem to Brooklyn, Lionel goes around New York to learn one thing - don’t cross path with the most powerful man in the city.
" Edward Norton isn’t just brilliant in front of the camera in movies like ’Primal Fear’, ’Fight Club’ and ’Moonrise Kingdom’, just to name a few. Norton is a director as well, and right now his second movie ’Mortherless Brooklyn’ is out. The film is based on Jonathan Lethems book by the same name from 1999 and revolves around the private eye Lionel Essrog, who has Tourette’s syndrome. Norton’s visual language is a love letter to New York of the 1950’s, while the director himself plays the tenacious detective. "